The HGH benefits are many, and this leads many people to abuse the compound. They believe if they use more, they’ll experience better results, but this is not at all the case. In fact, this is another similarity between HGH and anabolic steroids – both can cause severe side effects when used in high doses or for long periods of time. Per Dr. Alan Rogol, a representative of The Endocrine Society, HGH can weaken the muscles and cause heart disease when abused. He also notes that the bioavailability of oral HGH is too low for it to be effective, so those purchasing so-called HGH pills online are likely throwing their money away. Finally, per the FDA, excessive use can lead to a variety of cancers. This is why the use of exogenous HGH is so heavily regulated.
Follistatin (also known as activin-binding protein) is an autocrine glycoprotein encoded FST gene which is produced in almost all tissues. Its primary function in the body is bioneutralization members of the TGF-β family of proteins, with special focus on activin and paracrine hormones. Follistatin is a potent inhibitor of myostatin. Original follistatin also worked as an inhibitor of activin, which in turn stimulates secretion of follicle stimulating hormone - FSH (activin regulates the growth and differentiation of nearly all cell types, including the gonads, pituitary and skeletal muscle). For this reason, scientists have developed from the original follistatin derived specific follistatin (follistatin-344), which is preferably capable of blocking the effects of myostatin.