Flutamide and 2-hydroxyflutamide have been found in vitro to inhibit CYP17A1 (17α-hydroxylase/17,20-lyase), an enzyme which is required for the biosynthesis of androgens.  In accordance, flutamide has been found to slightly but significantly lower androgen levels in GnRH analogue-treated male prostate cancer patients  and women with polycystic ovary syndrome .  As such, flutamide is a weak inhibitor of androgen biosynthesis.  However, the clinical significance of this action may be limited when flutamide is given without a GnRH analogue to non-castrated men, as the drug markedly elevates testosterone levels into the high normal male range via prevention of AR activation-mediated negative feedback on the hypothalamic–pituitary–gonadal axis in this context. 
Q. How could one boost metabolism by diet? I am aware for long that metabolism is the cause for poor health and how could one boost metabolism by diet? A. Metabolism, if it is not erroneous genetically; then it can be controlled or increased by any diet. What matters is the timing and regularity you feed yourself which uses your hormones and enzymes in your body to do the task they are for. This timing and regularity depends on eating in same time regularly and working and sleeping too. To excite some hormones even if they had switched off their action in body, can be excited by exercise and feeding with small diets in regular short time intervals. To make all this happen, reduce on junk foods, please.