I have these exact symptoms. Use to be just a random itchy rash on my neck or face (I thought it was from mildew in our basement), it progressed to entire limbs itching (and of coarse swelling) in about 6 months. I have tried things in my own like probiotics, DIM, and Epsom salt bath. Then turned to the stinging nettle capsules, mixed herbal teas, and putting a dash of tumeric in food every day. I don’t get near as bad of outbreaks (maybe a red spot that I scratched here and there). I never linked the cramps and the bowl movements in the morning to it though – time to look up natural healing for my gut. Thank you!
To qualify for treatment with omalizumab, patients also must have a positive skin test (IgE level between 30 IU per mL and 700 IU per mL) or in vitro reactivity to a perennial inhaled allergen and their asthma should be uncontrolled with inhaled oral corticosteroids. 1 Inhaled corticosteroids should not be abruptly stopped at initiation of omalizumab treatment. The usual dosage of omalizumab is 150 to 375 mg subcutaneously every 2 or 4 weeks, based on patient weight and serum total IgE level (measured before treatment is started). The drug should be administered in the office to observe the patient for anaphylaxis. Effectiveness is monitored via symptom response.
The use of cromolyn (Intal), a mast cell stabilizer, has shown variable results in the prophylactic treatment of patients with exercise-induced anaphylaxis. 20 , 22 This agent prevents mast cell degranulation and release of plasma histamine and other inflammatory mediators, and may prove to be a viable option in this condition. However, it remains unknown if inhaled mast cell stabilizers, administered on a daily basis, maintain sufficient systemic concentration levels necessary to be adequately prophylactic against exercise-induced anaphylaxis.