Estradiol's efficacy seems to vary widely with the person and the particular vehicle: I was on transdermal patches for two years ( , 2 patches changed twice weekly – considered a "high" dose of 17-beta estradiol), and my levels mostly stayed around 100 pg/mL, and I needed 100mg spironolactone daily to keep my testosterone down. When I switched to injections of Estradiol Valerate, as I was "titrating up" my testosterone was unmeasurably low at the same E2 level my patches were delivering. (I had decided to drop spiro at the same time due to it's side effects: for me it seemed to be fogging my brain and inducing suicidal ideation.) Increasing the dosage had the effect of adding a cup-size to my breasts after about two months of injections, after two years of HRT, at age 53 and with b-cup breasts already. This story is not unusual in the community, and it led me to try this form of HRT.
Anabolic androgenic steroids (AAS) were initially created for therapeutic purposes, and synthetic derivatives of the male hormone testosterone. Due its great anabolic effects, these drugs are being used on a large scale, for the improvement of sports performance. In this present study, we aim to show the history of it’ use, present their mechanisms of action, more particularly its use correlate with improved body composition, muscle mass, aerobic capacity and verify their possible side effects, analyzing their use therapeutic and indiscriminate, through direct scientific research with the sports. Sources were reviewed scientific the following search engines: PUBMED, LILACS and SCIELO. The results showed that in presence of a suitable AAS and diet can contribute to increases in body weight, particularly lean body mass and muscle strength gains achieved by high intensity exercise, these effects can be further potentiated, the use of supraphysiological doses, but in the aspect of aerobic power, there are not scientific evidence to support their improvement. Regarding side effects, the use of AAS, is related to several complications in the liver, cardiovascular system, reproductive system and psychological characteristics, always assigned by the non-therapeutic and abuse of AAS. Thus we conclude that the use of AAS, are directly linked to gains muscle mass, strength, as well several side effects, always assigned to abusive and indiscriminate doses, it is noteworthy that the scientific literature, still has a certain lack of studies, mainly randomized, controlled, with supraphysiological doses in human, so many effects are still unknown.
Usual dosage for men is between 50 to 150 mg mesterolone daily. Period of 12 weeks is long enough time for effects of Mesterolone to manifest. Many bodybuilders prefers to use it during definition period and pre-competition training, when particularly desirable are low levels of estrogen and high levels of androgens. Mesterolone is recommended for use in combination with a low-power androgen (Oxandrolone, Methenolone, Stanozolol).In this case, mesterolone adjusts the ratio of androgens to estrogen and helps to increase strength and muscle density, promotes libido and overall sense of well-being and helps to burn fat.